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Itraconazole Dusting Powder

Itraconazole 1% Dusting Powder is a broad spectrum antifungal medicine used to treat skin infections like athlete's foot, jock itch, ringworm, etc. It is also used for relieving symptoms of these infections such as burning, itching, and cracking of the skin. It works by stopping the growth of fungi.

  • Composition

    Itraconazole 1% w/w

  • Release form

    Dusting Powder

  • Category

    For Derma Care

Indications

For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.

Pharmacology

Itraconazole is an allylamine which has a broad spectrum of antifungal activity. At low concentrations Itraconazole is fungicidal against dermatophytes, moulds and certain dimorphic fungi. The activity versus yeasts is fungicidal or fungistatic depending of the species. Itraconazole interferes specifically with fungal sterol biosynthesis at an early step. This leads to a deficiency in ergosterol and to an intracellular accumulation of squalene, resulting in fungal cell death. Itraconazole acts by inhibition of squalene epoxidase in the fungal cell membrane. The enzyme squalene epoidase is not linked to the cytochrome P450 system.