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Xylometazoline HCL Nasal Spray

Xylometazoline is a medication used to reduce symptoms of nasal congestion, allergic rhinitis, and sinusitis. Use is not recommended for more than seven days. It is used directly in the nose as a spray or drops. A nasal vasoconstricting decongestant drug which acts by binding to the same receptors as adrenaline. It is applied as a spray or as drops into the nose to ease inflammation and congestion of the nasal passageways. It binds alpha-adrenergic receptors to activate the adrenal system which causes systemic vasoconstriction, thereby easing nasal congestion.

  • Composition

    Xylometazoline HCL 0.1% w/w

  • Release form

    Nasal Spray

  • Category

    Nasal Congestion


Congestion, sinus (treatment)]—Nasal xylometazoline is used for the relief of sinus congestion. It is used for treating nasal congestion and minor inflammation due to allergies or colds.


Xylometazoline is a direct acting sympathomimetic drug, which acts on alpha-adrenergic receptors in the arterioles of the nasal mucosa. This activates the adrenal system to yield systemic vasoconstrction. In producing vasoconstriction, the result is a decrease in blood flow in the nasal passages and consequently decreased nasal congestion.


Contraindicated in patients hypersensitive to drug and patients with acute angle-closure glaucoma. Use cautiously in patients with hyperthyroidism, cardiac disease, hypertension, diabetes mellitus, and advanced arteriosclerosis.

Side Effects

Trouble sleeping, irritation of the nose, nausea, headache, and Long term use is not recommended due to a rhinitis medicamentosa when stopped.